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Book
Practical Tools for Designing and Weighting Survey Samples
Authors: --- ---
ISBN: 331993631X 3319936328 Year: 2018 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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The goal of this book is to put an array of tools at the fingertips of students, practitioners, and researchers by explaining approaches long used by survey statisticians, illustrating how existing software can be used to solve survey problems, and developing some specialized software where needed. This volume serves at least three audiences: (1) students of applied sampling techniques; 2) practicing survey statisticians applying concepts learned in theoretical or applied sampling courses; and (3) social scientists and other survey practitioners who design, select, and weight survey samples. The text thoroughly covers fundamental aspects of survey sampling, such as sample size calculation (with examples for both single- and multi-stage sample design) and weight computation, accompanied by software examples to facilitate implementation. Features include step-by-step instructions for calculating survey weights, extensive real-world examples and applications, and representative programming code in R, SAS, and other packages. Since the publication of the first edition in 2013, there have been important developments in making inferences from nonprobability samples, in address-based sampling (ABS), and in the application of machine learning techniques for survey estimation. New to this revised and expanded edition: • Details on new functions in the PracTools package • Additional machine learning methods to form weighting classes • New coverage of nonlinear optimization algorithms for sample allocation • Reflecting effects of multiple weighting steps (nonresponse and calibration) on standard errors • A new chapter on nonprobability sampling • Additional examples, exercises, and updated references throughout Richard Valliant, PhD, is Research Professor Emeritus at the Institute for Social Research at the University of Michigan and at the Joint Program in Survey Methodology at the University of Maryland. He is a Fellow of the American Statistical Association, an elected member of the International Statistical Institute, and has been an Associate Editor of the Journal of the American Statistical Association, Journal of Official Statistics, and Survey Methodology. Jill A. Dever, PhD, is Senior Research Statistician at RTI International in Washington, DC. She is a Fellow of the American Statistical Association, Associate Editor for Survey Methodology and the Journal of Official Statistics, and an Assistant Research Professor in the Joint Program in Survey Methodology at the University of Maryland. She has served on several panels for the National Academy of Sciences and as a task force member for the American Association of Public Opinion Research’s report on nonprobability sampling. Frauke Kreuter, PhD, is Professor and Director of the Joint Program in Survey Methodology at the University of Maryland, Professor of Statistics and Methodology at the University of Mannheim, and Head of the Statistical Methods Research Department at the Institute for Employment Research (IAB) in Nürnberg, Germany. She is a Fellow of the American Statistical Association and has been Associate Editor of the Journal of the Royal Statistical Society,Journal of Official Statistics, Sociological Methods and Research, Survey Research Methods, Public Opinion Quarterly, American Sociological Review, and the Stata Journal. She is founder of the International Program for Survey and Data Science and co-founder of the Coleridge Initiative.


Book
Lectures on Categorical Data Analysis
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ISBN: 1493976931 1493976915 Year: 2018 Publisher: New York, NY : Springer US : Imprint: Springer,

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This book offers a relatively self-contained presentation of the fundamental results in categorical data analysis, which plays a central role among the statistical techniques applied in the social, political and behavioral sciences, as well as in marketing and medical and biological research. The methods applied are mainly aimed at understanding the structure of associations among variables and the effects of other variables on these interactions. A great advantage of studying categorical data analysis is that many concepts in statistics become transparent when discussed in a categorical data context, and, in many places, the book takes this opportunity to comment on general principles and methods in statistics, addressing not only the “how” but also the “why.” Assuming minimal background in calculus, linear algebra, probability theory and statistics, the book is designed to be used in upper-undergraduate and graduate-level courses in the field and in more general statistical methodology courses, as well as a self-study resource for researchers and professionals. The book covers such key issues as: higher order interactions among categorical variables; the use of the delta-method to correctly determine asymptotic standard errors for complex quantities reported in surveys; the fundamentals of the main theories of causal analysis based on observational data; the usefulness of the odds ratio as a measure of association; and a detailed discussion of log-linear models, including graphical models. The book contains over 200 problems, many of which may also be used as starting points for undergraduate research projects. The material can be used by students toward a variety of goals, depending on the degree of theory or application desired.


Book
Foundations of Biostatistics
Authors: ---
ISBN: 9811086273 9811086265 Year: 2018 Publisher: Singapore : Springer Singapore : Imprint: Springer,

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This book offers a comprehensive guide to essential techniques and methods in biostatistics, addressing the underlying concepts to aid in comprehension. The use of biostatistics techniques has increased manifold in the recent past, due to their suitability for applications in a wide range of problems in various fields. This book helps learners grasp the materials in detail, equipping them to use biostatistics techniques independently and confidently. The book starts with a summary of background materials, followed by methods and techniques. As such, with only minimum guidance from teachers, this book can provide materials for self-learning of biostatistics techniques with a deeper level of understanding. The first two chapters focus on fundamental concepts, sources of data, data types, organization of data, and descriptive statistics, followed by the basic probability concepts, distributions and sampling distributions needed in order to combine descriptive statistics with inferential techniques. Estimation and tests of hypotheses are illustrated in two separate chapters. Important measures of association, linear regression, analysis of variance and logistic regression, and proportional hazards models are then presented systematically, ensuring that the book covers the topics most essential to students and users of biostatistics in connection with a wide range of applications in various fields. The book has been carefully structured, and the content is presented in a sequence covering the essential background in a highly systematic manner, supporting the learning process by presenting theory and applications that complement one another.


Book
Biopharmaceutical Applied Statistics Symposium : Volume 2 Biostatistical Analysis of Clinical Trials
Authors: --- ---
ISBN: 9811078254 9811078262 Year: 2018 Publisher: Singapore : Springer Nature Singapore : Imprint: Springer,

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This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials.  The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter. The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications.   This book is the second of the 3-volume book series. The topics covered include: Statistical Approaches to the Meta-analysis of Randomized Clinical Trials, Collaborative Targeted Maximum Likelihood Estimation to Assess Causal Effects in Observational Studies, Generalized Tests in Clinical Trials, Discrete Time-to-event and Score-based Methods with Application to Composite Endpoint for Assessing Evidence of Disease Activity-Free , Imputing Missing Data Using a Surrogate Biomarker: Analyzing the Incidence of Endometrial Hyperplasia, Selected Statistical Issues in Patient-reported Outcomes, Network Meta-analysis, Detecting Safety Signals Among Adverse Events in Clinical Trials, Applied Meta-analysis Using R, Treatment of Missing Data in Comparative Effectiveness Research, Causal Estimands: A Common Language for Missing Data, Bayesian Subgroup Analysis with Examples, Statistical Methods in Diagnostic Devices, A Question-Based Approach to the Analysis of Safety Data, Analysis of Two-stage Adaptive Seamless Trial Design, and Multiplicity Problems in Clinical Trials – A Regulatory Perspective.


Book
Multivariate Analysis of Ecological Data with ade4
Authors: --- --- --- --- --- et al.
ISBN: 1493988506 1493988484 Year: 2018 Publisher: New York, NY : Springer New York : Imprint: Springer,

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This book introduces the ade4 package for R which provides multivariate methods for the analysis of ecological data. It is implemented around the mathematical concept of the duality diagram, and provides a unified framework for multivariate analysis. The authors offer a detailed presentation of the theoretical framework of the duality diagram and also of its application to real-world ecological problems. These two goals may seem contradictory, as they concern two separate groups of scientists, namely statisticians and ecologists. However, statistical ecology has become a scientific discipline of its own, and the good use of multivariate data analysis methods by ecologists implies a fair knowledge of the mathematical properties of these methods. The organization of the book is based on ecological questions, but these questions correspond to particular classes of data analysis methods. The first chapters present both usual and multiway data analysis methods. Further chapters are dedicated for example to the analysis of spatial data, of phylogenetic structures, and of biodiversity patterns. One chapter deals with multivariate data analysis graphs. In each chapter, the basic mathematical definitions of the methods and the outputs of the R functions available in ade4 are detailed in two different boxes. The text of the book itself can be read independently from these boxes. Thus the book offers the opportunity to find information about the ecological situation from which a question raises alongside the mathematical properties of methods that can be applied to answer this question, as well as the details of software outputs. Each example and all the graphs in this book come with executable R code.


Book
Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents
Authors: --- --- ---
ISBN: 4431555730 4431555722 Year: 2018 Publisher: Tokyo : Springer Japan : Imprint: Springer,

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This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two agents. Development of dose-finding methods for two-agent combination trials requires reasonable models that can adequately capture joint toxicity probabilities for two agents, taking into consideration possible interactions of the two agents on toxicity probability such as synergistic or antagonistic effects. Another is clinical trials for evaluating both efficacy and toxicity outcomes in single- and two-agent combination trials. These methods are often applied to the phase I trials including MTAs because the toxicity and efficacy for a MTA does not monotonically increase with dose, but the efficacy often increases initially with the dose and then plateaus. Successful software implementations for several dose-finding methods are introduced in the book, and their operating characteristics in practice are discussed. Recent advance of the adaptive dose-finding methods in drug developments are also provided.


Book
Biopharmaceutical Applied Statistics Symposium : Volume 1 Design of Clinical Trials
Authors: --- ---
ISBN: 9811078289 9811078297 Year: 2018 Publisher: Singapore : Springer Nature Singapore : Imprint: Springer,

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Abstract

This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials.  The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter. The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications.   This book is the first of the 3-vol ume book series. The topics covered include: A Statistical Approach to Clinical Trial Simulations, Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design, Adaptive Trial Design in Clinical Research, Best Practices and Recommendations for Trial Simulations in the Context of Designing Adaptive Clinical Trials, Designing and Analyzing Recurrent Event Data Trials, Bayesian Methodologies for Response-Adaptive Allocation, Addressing High Placebo Response in Neuroscience Clinical Trials, Phase I Cancer Clinical Trial Design: Single and Combination Agents, Sample Size and Power for the Mixed Linear Model, Crossover Designs in Clinical Trials, Data Monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures, Design and Data Analysis for Multiregional Clinical Trials – Theory and Practice, Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines, Development and Validation of Patient-reported Outcomes, Interim Analysis of Survival Trials: Group Sequential Analyses, and Conditional Power – A Non-proportional Hazards Perspective.


Book
Biopharmaceutical Applied Statistics Symposium : Volume 3 Pharmaceutical Applications
Authors: --- ---
ISBN: 981107819X 9811078203 Year: 2018 Publisher: Singapore : Springer Nature Singapore : Imprint: Springer,

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This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials.  The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter. The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications.   This book is the third of the 3-volume book series. The topics covered include: Targeted Learning of Optimal Individualized Treatment Rules under Cost Constraints, Uses of Mixture Normal Distribution in Genomics and Otherwise, Personalized Medicine – Design Considerations, Adaptive Biomarker Subpopulation and Tumor Type Selection in Phase III Oncology Trials, High Dimensional Data in Genomics; Synergy or Additivity - The Importance of Defining the Primary Endpoint, Full Bayesian Adaptive Dose Finding Using Toxicity Probability Interval (TPI), Alpha-recycling for the Analyses of Primary and Secondary Endpoints of Clinical Trials, Expanded Interpretations of Results of Carcinogenicity Studies of Pharmaceuticals, Randomized Clinical Trials for Orphan Drug Development,  Mediation Modeling in Randomized Trials with Non-normal Outcome Variables, Statistical Considerations in Using Images in Clinical Trials, Interesting Applications over 30 Years of Consulting, Uncovering Fraud, Misconduct and Other Data Quality Issues in Clinical Trials, Development and Evaluation of High Dimensional Prognostic Models, and Design and Analysis of Biosimilar Studies.


Book
Epidemics : Models and Data using R
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ISBN: 3319974874 3319974866 Year: 2018 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This book is designed to be a practical study in infectious disease dynamics. The book offers an easy to follow implementation and analysis of mathematical epidemiology. The book focuses on recent case studies in order to explore various conceptual, mathematical, and statistical issues. The dynamics of infectious diseases shows a wide diversity of pattern. Some have locally persistent chains-of-transmission, others persist spatially in ‘consumer-resource metapopulations’. Some infections are prevalent among the young, some among the old and some are age-invariant. Temporally, some diseases have little variation in prevalence, some have predictable seasonal shifts and others exhibit violent epidemics that may be regular or irregular in their timing. Models and ‘models-with-data’ have proved invaluable for understanding and predicting this diversity, and thence help improve intervention and control. Using mathematical models to understand infectious disease dynamics has a very rich history in epidemiology. The field has seen broad expansions of theories as well as a surge in real-life application of mathematics to dynamics and control of infectious disease. The chapters of Epidemics: Models and Data using R have been organized in a reasonably logical way: Chapters 1-10 is a mix and match of models, data and statistics pertaining to local disease dynamics; Chapters 11-13 pertains to spatial and spatiotemporal dynamics; Chapter 14 highlights similarities between the dynamics of infectious disease and parasitoid-host dynamics; Finally, Chapters 15 and 16 overview additional statistical methodology useful in studies of infectious disease dynamics. This book can be used as a guide for working with data, models and ‘models-and-data’ to understand epidemics and infectious disease dynamics in space and time.


Book
The Measurement of Association : A Permutation Statistical Approach
Authors: --- ---
ISBN: 331998926X 3319989251 Year: 2018 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This research monograph utilizes exact and Monte Carlo permutation statistical methods to generate probability values and measures of effect size for a variety of measures of association. Association is broadly defined to include measures of correlation for two interval-level variables, measures of association for two nominal-level variables or two ordinal-level variables, and measures of agreement for two nominal-level or two ordinal-level variables. Additionally, measures of association for mixtures of the three levels of measurement are considered: nominal-ordinal, nominal-interval, and ordinal-interval measures. Numerous comparisons of permutation and classical statistical methods are presented. Unlike classical statistical methods, permutation statistical methods do not rely on theoretical distributions, avoid the usual assumptions of normality and homogeneity of variance, and depend only on the data at hand. This book takes a unique approach to explaining statistics by integrating a large variety of statistical methods, and establishing the rigor of a topic that to many may seem to be a nascent field. This topic is relatively new in that it took modern computing power to make permutation methods available to those working in mainstream research. Written for a statistically informed audience, it is particularly useful for teachers of statistics, practicing statisticians, applied statisticians, and quantitative graduate students in fields such as psychology, medical research, epidemiology, public health, and biology. It can also serve as a textbook in graduate courses in subjects like statistics, psychology, and biology.

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